Decoding HIV resistance: from genotype to therapy
نویسندگان
چکیده
منابع مشابه
HIV therapy: managing resistance.
O the last years, a number of potent drugs have been developed that inhibit HIV-1 replication in vivo. Treatment regimes involving a combination of three or more different drugs can induce a decline in virus load by several orders of magnitude, as well as a significant rise in the CD4 cell count. The drugs currently in use mainly fall into two classes: reverse transcriptase inhibitors prevent i...
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Drug resistance testing has been shown to be beneficial for clinical management of HIV type 1 infected patients. Whereas phenotypic assays directly measure drug resistance, the commonly used genotypic assays provide only indirect evidence of drug resistance, the major challenge being the interpretation of the sequence information. We analyzed the significance of sequence variations in the prote...
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ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2017
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc-2017-0048